Fig. 3
From: Radiotherapy combined with nano-biomaterials for cancer radio-immunotherapy
Reproduced from ref 22. Copyright 2021, Elsevier Ltd. g M2-like macrophages (CD11b+F4/80+CD206+). h MDSCs (CD45+CD11b + Gr-1+). i, j The levels of IL-6 (i) and TNF-α (j) in tumors with different treatments as indicated. Reproduced from ref 59. Copyright 2023, Wiley–VCH GmbH
Nano-biomaterial-enabled regulation of the hypoxic and oxidation-stressed tumor microenvironment regulation for radio-immunotherapy. a Schematic illustration of enhancing anti-tumor immunotherapy by radioactive nano-oxygen generator. b Distant tumor growth curves of mice model. c The percentage of tumor-infltrating CD8+ T cells (G1: PBS + Surgery, G2: APPs-PEG + Surgery, G3: PBS + 177Lu-APPs-PEG, G4: 177Lu-APPs-PEG + APPs-PEG). d–f The immunofluorescence slices showing the expression of HIF-1α (d), c-Myc (e) and Ki67 (f) in tumors.