G-M-based nano-delivery systems for synergistic therapy involving ST, CDT, EDT, IMT, CT, PTT, SDT, and PDT. In this synergistic therapy strategy, the constructed NPs include MOF NPs, biomineralization-based NPs, metal oxide NPs, noble metal NPs, DMSN NPs, and polymer NPs. (The permutation in the diagram does not contain an ownership relationship. For example, the two NPs under the ST block do not only complete the ST)