Table 5 Novel drug delivery systems in clinical development
Treatment modality | System | Component | Example | References |
|---|---|---|---|---|
Noninvasive | Controlled release capsule (medicine) | Small molecule compounds | Hawthorn Leaf Total Flavonoids Extended-Release Capsules | [208] |
Inhalable devices | Compound prescription (Chinese medicine) | Nebulized inhalation of Chinese medicine | [209] | |
Liposome | Small molecule compounds | Honokiol Liposome lyophilized powder | [210] | |
Nanoparticles | Small molecule compounds | Astragalus polysaccharide nanotumor in situ vaccine | [211] | |
Transdermal patches | Monomers of Chinese medicine | Chinese Medicine Acupuncture Point Patching | [212] | |
Invasive | Microneedle | Compound prescription (Chinese medicine) | “Jade Face” soluble microneedle | [213] |
Implant | Monomers of Chinese medicine | Epimedium extract nanotube biomimetic coating | [214] | |
Microsphere | Small molecule compounds | Huperzine A Slow-release microspheres | [215] | |
Liposome/nanoparticles | Small molecule compounds | Ursolic acid nanoliposomes; Paclitaxel liposome | ||
Hypodermic injection | Small molecule compounds | Paclitaxel polymer micelles for injection | [218] |