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Fig. 8 | Journal of Nanobiotechnology

Fig. 8

From: Recent advancements in nanomaterial-laden contact lenses for diagnosis and treatment of glaucoma, review and update

Fig. 8

(a) Cleavage of Tamra-pep by MMP-9 on SERS substrate. (b) Raman spectra of Tamra-pep on AuNBs after MMP-9 treatment. (c) Linear calibration curve for Raman intensity ratios and MMP-9 concentration. (d) SERS responses to MMP-9, trypsin, and lysozyme. (e) Repetitive MMP-9 detection on CLs. (f) Raman spectra after MMP-9 incubation. (g) SERS responses after multiple MMP-9 treatments. (h) Stability test over seven days. (i) SERS intensity ratios over time with MMP-9 cleavage. (j) Fluorescence kinetics of MMP-9 and Tear #5. k) MMP-9 level on fluorescent assay calibration curve. l) Comparison of measured and calculated MMP-9 concentrations [97]

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