Scheme 1
From: High-precision detection and navigation surgery of colorectal cancer micrometastases
Schematic illustrating FE-2PEG for NIR-II FGS for CRC. a NIR-II FGS with D-A-D dye FE-2PEG of orthotopic CRC with lymphatic metastasis. LNs, lymph nodes. b NIR-II imaging navigation with FE-2PEG was used in FGS of PM. Supplementary biopsies with the naked eyes were carried out for diagnostic experiments. The nodules that FGS resected were classified into three subgroups according to the diameters for further analysis of the diagnostic experiment. FL, fluorescence. c Dual-NIR-II color probes were designed with D-A-D dye FE-2PEG at the NIR-IIa window and PbS@CdS QDs at the NIR-IIb window for simultaneously visualizing the mesenteric LNs and surrounding blood vessels. d NIR-II microscopic fluorescence images for intraoperative diagnosis