Fig. 5
From: Probing milk extracellular vesicles for intestinal delivery of RNA therapies
In vivo efficacy of milk extracellular vesicles (mEVs) loaded with anti-tumour necrosis factor alpha (TNFα) small interfering RNA (siRNA) in a rat model of ulcerative colitis. A Macroscopic presentation. B Macroscopic Score. C Histological sections (H&E 100x); a control, b vehicle (unloaded mEVs) and c anti TNFα siRNA loaded mEVs. D Histological Score. ‘Vesicle’ denotes treatment with electroporated, non-drug loaded mEVs at the same dose as siRNA loaded mEVs. Ulcerative colitis was induced via administration of 4,6-trinitrobenzene-sulfonic acid (TNBS). Data are presented as mean ± SD (n = 3). * Indicates p < 0.05