Fig. 5
From: Mannose-doped metal-organic frameworks induce tumor cell pyroptosis via the PERK pathway
Antitumor activity of M-FNM against SCC-7 tumor xenografts in mice. (A) Treatment schedule of utilizing M-FNM for antitumor therapy. (B-C) Tumor volume and body weight of SCC-7-tumor-bearing mice with different treatments (C57BL/6J, n = 5). Mice received PBS, Mannose, Fe3O4, FNM, or M-FNM injection (10 mg/kg), respectively. (D) Histological images of SCC-7 tumors after different treatments. (E) CLSM fluorescence images of cleaved Caspase-1 in tumor after various treatments. Compared to control, *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.001