Fig. 4
CeO2@RSV directly changes the inflammation status and affects the apoptosis of ovarian tissues in PCOS mice. A Experimental protocol for the therapeutic treatment of PCOS in mice. B ELISA results of IL1-β and IL-10 levels in the serum of each group (n = 5). C RT-PCR analysis of the mRNA expression levels of IL1-β, iNOS and IL-10 in the ovarian tissues of each group. D The ratio of M1 (F4/80+CD11c+)/M2 (F4/80+CD163+) macrophages in the spleens of mice from the indicated groups was analyzed by flow cytometry. E Representative images of TUNEL assay results in mouse ovaries from the indicated groups. Scale bar: 50 µm. F Western blot analysis of the Bcl2/Bax ratio in the ovarian tissues of each group. *P < 0.05, **P < 0.01, ***P < 0.001