Fig. 7
The JAK-STAT signaling pathway is responsive to the treatment of CeO2@RSV during PCOS. A ELISA results of IL-1β and IL-10 levels in the supernatants of CeO2@RSV-treated M1 macrophages incubated with or without WP1066. B Flow cytometry analysis of specific markers of M1 (CD86) and M2 (CD206) macrophages in different experimental treatment groups. C The protein expression of STAT3 and p-STAT3 in the three groups. D Representative images and quantification of EdU (+) in KGN cells. E Western blot analysis of Bcl2/Bax in KGN cells. F Apoptosis of KGN cells in each group was detected by flow cytometry. G ELISA results of IL1-β and IL-10 levels in the serum of each group. H A TUNEL assay was used to detect apoptosis in ovarian tissues in vivo. I Representative HE staining of ovarian sections from the experimental mice. J The number of CFs and CLs in the ovaries of the mice in each group. *P < 0.05, **P < 0.01, ***P < 0.001. K, L Glucose tolerance tests and AUCs of the indicated groups. n = 5, *P < 0.05, **P < 0.01, ***P < 0.001 vs. the PCOS group; #P < 0.05, ##P < 0.01 vs. the CeO2@RSV group