Table 3 ELPs used to form peptide-drug conjugates discussed in this review

(VPGVG)₈₀(VPGSG)₆₀

-

R_h:41.8

R_g:37.2

Telechelic hydroxylamine

Targeted toxicity to multiple cancer cell lines

[91]

(XGVPG)₁₆₀

X = V: G: A = 1:7:8

4.2 ± 1.34

R_h:30.1 ± 10.4

R_g:81.5 ± 5.8

(GGC)₈

Increase NIC tumor accumulation,

Enhance antitumor activity

[120]

(VPGAG)₁₆₀

29.4 ± 0.8

40–50

Albumin-binding domain (ABD)

Nanoscale affinity for human and mouse albumin

Improved pharmacokinetic profile

Prolonge intratumoral retention time

[121]

(AGVPG)₁₆₀

12.8 ± 2.2

R_h:56

R_g:57

(YG)₆(CGG)₈

Plasma half-life prolongation

Increased tumor accumulation

Tumor suppressor effect is better than free drug

[122]