Table 4 ELPs hydrogels for tissue repair discussed in this review

ELP-HYD

25

Dynamic covalent hydrazone bonds

-

Cultured cells maintain the ability to differentiate into multiple lineages.

[133]

ELP-SELR

24.6

-

L-Arg-Gly-L-Asp (RGD)

Encapsulate cells, maintain cell viability and cell proliferation ability

[136]

ELP-HA-SpyTag-TriCatcher

-

Spontaneous amidation

Protein partner (SpyCatcher)

Fibroblasts and breast epithelial cells can grow, separate, and spread.

[137]

YIGSR/RGD-ELP

-

-

Cell-adhesive domains RGD

cell-adhesive ligand YIGSR

Increase matrix hardness,

Increase adipogenic and osteogenic differentiation markers.

[145]

ELP, SDBS, DEAB, DDAB

37

Supramolecular assembly

L-Arg-Gly-L-Asp (RGD)

Acumulation of intracellular CaP,

Promote osteogenic differentiation of BMSCs

[147]

K₇₂-ELP,

CS,

PEG-COO⁻

-

Amino groups interact with carboxylate and sulfonate groups

Chondroitin sulfate

Repair damaged cartilage,

Enhance horizontal integration of tissues.

[148]

Silk-ELP,

60

Dehydrothermal

ELP

Support the adhesion, proliferation and differentiation of BMSCs or chondrocytes,

Enhance cartilage tissue repair

[149]

ELP,

Collagen gel

25

Hydrogen bond,

hydrophobic interactions

Cell-binding domains RGD

enzymatically degradable sequences (GTAR)

Produce cellularized tubular structures,

Reproduce mechanical behavior of vascular ECM.

[150]

ELPs,

PEG,

IKVAV

Thiol-ene photo-cross-linking reactions

Adhesion peptide IKVAV

No obvious inflammation,

Induce the formation of blood vessels and nerve endings in tissues.

[151]