Fig. 6

Visualized treatment of GQDs/Cy5-miR@sEVs in the tumor-bearing murine model. A The miR-193a-3p in GQDs/Cy5-miR@sEVs and Cy5-miR@sEVs was detected by qRT-PCR. B Scheme illustrating GQDs/Cy5-miR@sEVs treatment in subcutaneous xenograft tumor model established by HGC-27 cells in BALB/c nude mice. C The in vivo tumor volumes were monitored over time during four injection cycles. D, E The fluorescence intensity of tumor region was monitored and plotted over time. F Images of subcutaneous xenograft tumors in mice in each group (n = 5) when the tumor sizes were measured ex vivo. G Tumor weights of mice in each group were measured. H Western blot assays detected the expression of CCND1 protein in different treatments. I Ki-67 and J TUNEL staining of tumors from mice in different groups. Scale bars = 50 μm. One-way ANOVA for multiple groups was applied for statistical analysis. ns, no significance; **p < 0.01 and ***p < 0.001