Fig. 7
From: Visualization of microRNA therapy in cancers delivered by small extracellular vesicles
The biosafety evaluation of GQDs/Cy5-miR@sEVs in vivo. BALB/c nude mice were sacrificed after administration with PBS, sEVs, Cy5-miR@sEVs and GQDs/Cy5-miR@sEVs. A Body weights of mice subject to different treatments as indicated. B The major organs of mice in each group including liver, spleen, heart, lung, and kidney were collected for H&E staining. C The measured levels of biochemical indicators in the mouse blood samples, including the indices for liver (ALT and AST) and kidney (BUN and CREA). Data are expressed as mean ± SD and analyzed by one-way ANOVA. ns, no significance