Fig. 11

In vivo simultaneous dual-color PA imaging of a rat’s SLNs with injection of dual-color nanonaps (707 and 860 nm). A Control PA MAP image at 707 nm. A-a, A-b Control PA cross-sectional images of right and left axillary regions cut along the dotted lines a and b in A, respectively. B Control PA MAP image at 860 nm. B-a, B-b Control PA cross-sectional images of left and right axillary regions cut along the dotted lines a and b in B, respectively. 707 and 860 nm nanonaps (0.01 mL and 17.1 mg/mL) were injected simultaneously throughout the forepaw pads of both sides (i.e., left side; 707 nm nanonap and right side; 860 nm nanonap). C Post-injection PA image at 707 nm. C-a, C-b Corresponding PA cross sectional PA images cut along the dotted lines a and b in C. D Post-injection PA image at 860 nm. D-a, D-b Corresponding PA cross-sectional PA images cut along the dotted lines a and b in D. E Overlaid dual-color PA image of both right and left lymphatic systems. F Photograph of the dorsal region of the animal. SLN sentinel lymph node, LV lymphatic vessel, H head; and T tail. The figure was reused from the research article published in the journal Biomaterials by Lee, Lovell, Kim and co-workers in 2015 [202]