Fig. 9

Design of dual-modality HA-HPPS nanoparticles for mapping sentinel lymph nodes in breast cancer. A Components and structures of the CD44 and SR-B1 dual-targeting HA-HPPS nanoparticles. B Dual-modality fluorescence and photoacoustic imaging of HA-HPPS in SLNs, which includes near-infra-red (NIR) fluorescence imaging for long-term monitoring of the accumulation and retention of HA-HPPS in SLNs and photoacoustic microscopy (PAM) for intraoperative determination of the metastatic status of SLNs in breast cancer. The figure was reused from the research article published in the journal Light: Science and Applications by Dai, Luo, Zhang and co-workers in 2020 [174]