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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Synergistic cerium oxide nanozymes: targeting DNA damage and alleviating tumor hypoxia for improved NSCLC radiotherapy efficiency

Fig. 4

(A) Representative results of the A549 MTT assay in different groups including the control, RT, QT + RT, CeO2@ZIF-8-HA + RT, and C/Q@ZIF-8-HA + RT groups. The results from 24 and 48 h time points showing statistically significant difference. (B) CCK-8 assay was used to analyze the proliferation ability of five groups. (C) Western blotting analysis of cleaved PARP and γH2AX in control, RT, QT + RT, CeO2@ZIF-8-HA + RT, and C/Q@ZIF-8-HA + RT groups, respectively. (D) A colony of A549 cells treated with QT, CeO2@ZIF-8-HA, or C/Q@ZIF-8-HA combined X-ray (6 Gy). (E) Annexin V-FITC/PI staining was performed to determine the apoptosis of A549 cells in control, RT, QT + RT, CeO2@ZIF-8-HA + RT, and C/Q@ZIF-8-HA + RT groups. **P < 0.01

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