Fig. 5
A549 tumor-bearing BALB/c nude mice were injected intravenously with C/Q@ZIF-8-HA. The tumor-bearing BALB/c nude mice were randomly divided into five groups: (a) control group, (b) RT alone group, (c) QT + RT group, (d) CeO2@ZIF-8-HA + RT group, and (e) C/Q@ZIF-8-HA + RT group. (A) Body weight of A549 tumor-bearing BALB/c nude mice in each group over 14 days after treatment. (B) Tumor weights of different groups in A549 tumor-bearing BALB/c nude mice. (C) Tumor volumes of different groups in A549 tumor-bearing BALB/c nude mice. (D) ROS levels in tumor tissue after treatment in different groups. (E-F) Tumors were collected from five different groups 14 days after different treatments. The images of the tumors are displayed. (G) Representative hematoxylin-eosin staining in NSCLC tissue in five groups. Scale bar: 100 μm. (H-I) Representative HIF-1α immunohistochemical staining and relative expression intensity were observed in the 5 groups of tumor tissues. Scale bar: 20 μm. (J) The enzyme-linked immunosorbent assay of HIF-1α in five groups in tumor tissue. **P < 0.01