Fig. 2
Evaluation of site-specific photothermal-amplified thrombolytic effect and safety of PLT-PPy/Riv NPs in FeCl3-induced rats models of LEDVT. a Histological microscopic analysis of rat vessels after treatment with different formulations. Scale bar = 25 μm. b Quantification of thrombus clearance by the ratio of thrombolytic area/total lumen area (n = 3). c Qualitative and quantitative d analysis of the hemolysis activity of SDS-PPy/Riv NPs, PLT-PPy NPs, and PLT-PPy/Riv NPs at the same Riv concentration (n = 3). e The mice tail-cutting model for tail bleeding test. f The clotting time and g bleeding time in the tail bleeding test (n = 3). h The H&E sections of heart, liver, spleen, lung and kidney of PBS and PLT-PPy/Riv NPs treatment group for evaluating the histopathological changes. Scale bar = 25 μm. Statistical analysis was via one-way ANOVA with GraphPad Prism 8.0; ns: no significance, **P < 0.01, ***P < 0.001