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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Biomimetic platelet-camouflaged drug-loaded polypyrrole for the precise targeted antithrombotic therapy

Fig. 5

In vitro assessment of thrombus-targeting capabilities of PLT-PPy/Riv NPs. a Flow cytometry analysis of the adhesion of PLT-PPy/Riv NPs to activated and inactivated platelets and b quantitative analysis of fluorescence intensity (n = 3). c The adhesion of PLT-PPy/Riv NPs to activated and inactivated platelets observed by laser confocal microscopy. Platelets were stained with calcein-AM (green) and PLT-PPy/Riv NPs were labeled with DiD (red). Scale bar = 10 μm. d In vitro fluorescence signal in artificial blood clots (n = 3). e Quantitative analysis of fluorescence intensity in artificial blood clots (n = 3). Statistical analysis was via one-way ANOVA with GraphPad Prism 8.0; ****P < 0.0001

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