Fig. 6

In vitro clot lysis and in vivo thrombus targeting assessment of PLT-PPy/Riv NPs. a Quantitative analysis of in vitro thrombolysis of PBS, Riv Sol, SDS-PPy/Riv NPs, PLT-PPy NPs and PLT-PPy/Riv NPs after laser irradiation for 10 min. b Thrombosis model in animals induced by ferric chloride method. c In vivo fluorescence images of femoral vein vessels at 75 min post-injection of PLT-PPy/Riv NPs collected by using IVIS. d Quantitative analysis of the fluorescence intensity changes of DiD-labeled-PLT-PPy/Riv NPs at different time points after intravenous injection (n = 3). e In vivo photothermal imaging and f in vivo temperature change curves under 808 nm laser irradiation after administration of different formulations. Statistical analysis was via one-way ANOVA with GraphPad Prism 8.0; *P < 0.05, **P < 0.01