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Fig. 1 | Journal of Nanobiotechnology

Fig. 1

From: Ultrasound-targeted microbubble destruction promotes PDGF-primed bone mesenchymal stem cell transplantation for myocardial protection in acute Myocardial Infarction in rats

Fig. 1

Schematic representation of PDGF-BB-primed MSC transplantation by UTMD for infarcted myocardium repair. UTMD enhanced the delivery of MSCs into the infarcted myocardium by upregulating SDF-1 expression. Compared with UTMD alone, UTMD combined with PDGF-BB pretreatment increased the therapeutic effect of grafted cells by improving MSC migration and survival, reducing cardiomyocyte apoptosis, decreasing fibrosis, increasing microvessel density (via upregulation of VEGF, bFGF and IGF-1) and improving cardiac function. PDGF-BB promotes the survival/retention and cardioprotection of engrafted MSCs in rat models of MI via the PI3K/Akt pathway and CXCR4 activation

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Journal of Nanobiotechnology

ISSN: 1477-3155

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