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Fig. 10 | Journal of Nanobiotechnology

Fig. 10

From: Micro electrical fields induced MSC-sEVs attenuate neuronal cell apoptosis by activating autophagy via lncRNA MALAT1/miR-22-3p/SIRT1/AMPK axis in spinal cord injury

Fig. 10

Schematic representation of the regulatory role of the EF-sEVs lncRNA-MALAT1 in SCI via mediation of the miR-22-3p/SIRT1/AMPK axis. HucMSCs induced by microelectric fields increase the expression of lncRNA-MALAT1, which in turn is encapsulated into EF-sEVs. EF-sEVs delivered lncRNA-MALAT1 into neurons. LncRNA-MALAT1 sponges adsorbed miRNA-22-3p and promotes the SIRT1/AMPK signaling pathway, which induced autophagy to inhibited apoptosis, thereby EF-sEVs improving the motor function in hindlimbs after SCI in rats

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Journal of Nanobiotechnology

ISSN: 1477-3155

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