Fig. 2
Preparation and characterization of SCCI. A TEM image of SCCI. Scale bar, 200 nm. B Zeta potential of CaCO3, Cur, ICG, CCI, SCCI. Data are shown as mean ± SD (n = 3). C XRD spectrum of CaCO3 and CCI. D XPS spectra of SCCI. E Elemental mapping of SCCI. Scale bar, 250 nm. F FT-IR spectra of CaCO3, Cur@CaCO3, CaCO3@ICG, CCI and SCCI. G UV–vis-NIR absorbance spectra for the Cur, ICG, Cur@CaCO3, CCI, and SCCI. H Pictures of SCCI dispersed in PBS solutions of pH 5.0, 6.5 and 7.4 for 1 h and centrifuged for 10 min. I Time-dependent release profiles of Cur in SCCI incubated in PBS at different pH values. Data are shown as mean ± SD (n = 3). J Heating curve of SCCI solution for three on–off cycles with an 808 nm NIR laser (0.75 W/cm2, 5 min). K Photothermal heating curves of PBS, Cur, ICG, CCI and SCCI under an 808 nm laser irradiation (0.75 W/cm2, 5 min). L Temperature curve of SCCI solution with different concentration under 808 nm NIR laser irradiation. (0.75 W/cm2, 5 min). M Thermographic images of different concentrations of SCCI under 808 nm NIR laser irradiation. (0.75 W/cm2, 5 min)