Fig. 6
In vivo synergistic therapy of SCCI combined with NIR irradiation. A In vivo fluorescence images of tumor-bearing mice after intravenous injection of ICG and SCCI at the indicated time points. B Ex vivo fluorescence images of major organs (heart, liver, spleen, lung, kidney) and tumors after ICG and SCCI at 24 h post-injection. C Fluorescence intensity of isolated organs and tumors was quantified 24 h after injection. Data are shown as mean ± SD (n = 3). ****P < 0.0001. D Photothermal images of tumor sites after injected with different formulations (0.75W/cm2, 5 min). E Photothermal heating curves of tumor-bearing mice after injected with saline, Cur, ICG, CCI and SCCI with 808 nm laser irradiation (0.75W/cm2, 5 min). F In vitro tumor images of each group 24 h after the last administration. Data are shown as mean ± SD (n = 5). G Tumor volume variation in 4T1 tumor-bearing mice after treatment with different formulations. Data are shown as mean ± SD (n = 5)