Fig. 11

A Schematic illustration of the preparation of Man-VIPER-R and Man-VIPER-NR delivery systems, as well as their function in vivo. The formulations of self-assembled micelles are preferentially endocytosed via the mannosylated hydrophilic segment anddisassembled upon endosomal maturation.Then, it results in endosomal disruption and cross-presentation of MHC-I epitopes or lysosomal maturation and presentation of MHC-II epitopes to their own respective T-cell subsets. B Hemolytic activity of different micelles against human RBCs at pH 5.6, pH 6.2 and pH 7.4. C Scheme of the B16F10-OVA tumor model and treatment scheme of different drugs. Mice were vaccinated on days 3, 10, and 19 and treated with ICB on days 4, 11, and 20. D Tumor growth curve of the tumor-bearing mice from the different treatment groups (n = 8). E Kaplan‒Meier survival curve from the different treatment groups. Reproduced with permission from [146].