Fig. 5
Copyright 2021, American Chemical Society
A Structural schematic diagram and biological properties of pacMELClv and YPEG-MEL. B Chemical structures and schematic illustrations of PEGylated MEL. C Plasma pharmacokinetics of MLT-containing samples and free bottlebrush polymer in C57BL/6 mice. D Near-IR imaging of BALB/c mice bearing NCI-H358 xenografts 24Â h after i.v. injection with Cy5.5-labeled free MLT, pacMELClv, and bottlebrush polymer (Tumors are highlighted with orange circles). Ex vivo imaging of tumors and other major organs. E Biodistribution profile determined from image analysis. Reproduced with permission from [68].