Fig. 7From: Recent advances in melittin-based nanoparticles for antitumor treatment: from mechanisms to targeted delivery strategiesCopyright 2023, ElsevierA The hybrid peptide indicated specific binding in a defined location (proline 211) by fusing MLT and TAT sequences by a GGGS linker. The blue, yellow and red colors are related to the CD147 protein, peptide and binding site (proline 211), respectively. B TM was as follows (SLPALISWIKRKRQQGGGSRKKRRQRRR), and the specific binding was confirmed by cluspro docking. The blue, yellow and red colors are related to the CD147 protein, TM peptide and binding site in proline 211, respectively. C Coarse-grained simulation of the TM peptide interaction with the DOPC/DOPS model membrane after 1500 ns (yellow = water, red = protein, blue, pink, light gray = lipid). Reproduced with permission from [118].Back to article page