Fig. 8

A Schematic illustration of the fabrication and tumor-targeted therapy of MpG@LPN. B Cell apoptosis/necrosis analysis of A549 cells treated with PEGMpG@LPN and RGD-MpG@LPN by Annexin V/PI-FACS. C Caspase-3 activities in A549 cells treated with PEG-MpG@LPN and RGD-MpG@LPN. D Images of tumor-bearing nude mice at 6 h after the administration of DiR-labeled PEG-MpG@LPN and RGD-MpG@LPN and ex vivo tumors at 24 h postinjection. E Flowchart of the antitumor experiment in vivo. F Tumor growth of A549 xenograft mice treated with PBS, PEG-MpG@LPN, and RGD-MpG@LPN. G Changes in the body weight of tumor-bearing mice in different groups. Reproduced with permission from [128].