Fig. 5
From: Zn-Shik-PEG nanoparticles alleviate inflammation and multi-organ damage in sepsis
Protective effect of Zn-Shik-PEG NPs on LPS-induced multi-organ damage. (A-D) BUN, CRE, AST, ALT, levels in serum were detected by ELISA kits. (E) Lung index in each treatment group. (F) MPO activity was measured in lungs obtained 24 h after i.p. of LPS. (G) H&E staining of lung, spleen, heart, liver, kidney tissue. Green arrows indicate inflammatory cell infiltration; dark red arrow indicates interstitial thickening; black arrows indicate nuclear pyknosis; blue arrows indicate megakaryocytes; purple arrows indicate myocardial fiber breakage; dark blue arrows indicate hepatocellular necrosis; red arrow indicates renal tubule epithelial cell edema. Scale bar: 50 μm. Data are presented as mean ± SD (n = 3, 6). *p < 0.05, **p < 0.01, and ***p < 0.001