Fig. 7

Targeting atherosclerotic plaques by VHPK-PLGA@COL in vivo. a Representative ex vivo fluorescence images of aortas and major organs, b Quantitative data of DiR fluorescent signals accumulated in the aortas, c Heatmap of DiR fluorescent signals in major organs at 24 h post intravenous injection (n = 3, *P < 0.05, **P < 0.01, ***P < 0.001). d CLSM images of aortic sinus sections prepared from atherosclerotic mice after intravenous injection of saline, DiR-labeled VHPK-PLGA or VHPK-PLGA@COL for 24 h. (blue = DAPI, green = VCAM-1, red = nanoparticles, P = atherosclerotic plaque, L = vessel lumen, scale bar = 50 μm)