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Fig. 7 | Journal of Nanobiotechnology

Fig. 7

From: Carbon dot nanozymes as free radicals scavengers for the management of hepatic ischemia-reperfusion injury by regulating the liver inflammatory network and inhibiting apoptosis

Fig. 7

Therapeutic mechanisms of C-dots on HIRI. (A) Heat maps displaying the expression levels of noteworthy genes following C-dots administration (fold change ≥ 2 and P < 0.01). (B) The volcano plots displayed the genes that were upregulated and downregulated by C-dots. (C) The Venn diagram of RNA sequencing analysis of the entire transcriptome revealed variations in gene expression between the HIRI group and the control group, as well as between the C-dots group and the HIRI group. (D) Analysis of gene ontology (GO) including Molecular Function (MF), Biological Process (BP), and Cellular Components (CC). (E) Analysis of enrichment in KEGG pathways. Displayed were the top 20 pathways that exhibited the highest level of enrichment. (F) After treatment with C-dots, heat maps displaying significant genes related to the mitochondrion, glutathione metabolism, PPAR signaling pathway, and TGF-β signaling pathway were generated

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Journal of Nanobiotechnology

ISSN: 1477-3155

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