Recent trends in preparation and biomedical applications of iron oxide nanoparticles

Meng, Yu Qing; Shi, Ya Nan; Zhu, Yong Ping; Liu, Yan Qing; Gu, Li Wei; Liu, Dan Dan; Ma, Ang; Xia, Fei; Guo, Qiu Yan; Xu, Cheng Chao; Zhang, Jun Zhe; Qiu, Chong; Wang, Ji Gang

doi:10.1186/s12951-023-02235-0

Journal of Nanobiotechnology

Table 1 Summary of different types of iron oxide nanoparticles (IONPs) in animal models

From: Recent trends in preparation and biomedical applications of iron oxide nanoparticles

Coating molecule	Name	Model	Dose	Days	Outcome	References
Polyethylene glycol	PEG-MGNCs	SCC7 tumor-bearing mouse	8 mg/kg	8 days	Enhance the hyperthermia efficacy	[12]
Citrate	Citrate@IONPs	Elderly and young healthy mice	2.4 mg Fe/kg	28 days	Reasonably biocompatible for young mice	[16]
Polyethylene glycol	SaNPs	Swine	22 mg IO/kg, 3.6 mg IO/kg	90 days	No adverse effects	[40]
Chitosan	γ-Fe₂O₃/PLGA/CS NPs, γ-Fe₂O₃/PLGA NPs	BALB/c mice	5 mg/kg	1, 24 h	No toxicity in vital organs	[41]
c(RGDyK)and D-glucosamine	Fe₃O₄@RGD@GLU	BALB/c mice	30 mg Fe/kg	8 days	Tumors on mice were obviously inhibited	[42]
Macrophage membranes	Fe₃O₄@MM NPs	BALB/c mice	2.5 mg Fe/kg	16 days	Significantly reduce the tumor size	[43]
Dopamine sulfonate, zwitterionic dopamine sulfonate, coryneine chloride	FeOx NPs	CD1 mice	1 or 4 mg Fe/kg		Rapidly distributed in liver and spleen, and excreted via urinary system	[44]
/	Fe₃O₄ NPs	Swiss mice	1, 2 mg Fe/kg	12, 22 days	Significantly reduce the tumor growth	[45]
6 − 7 bovine serum albumin	Fe₂O₃@BSA	SD rats	0.15 mM Fe/kg	24, 48 h	Efficiently cleared within 48 h	[46]
Poly (ethylene glycol)-L-arginine	PEG-Arg@IONPs	BALB/c mice	20 mg Fe/kg	24 h	Mainly uptake by liver, besides spleen, heart and kidneys	[49]
Citrate, curcumin, chitosan	IONPs@citrate, IONPs@curcumin, IONPs@chitosan	Wistar rats	4 mg Fe/kg	10 days	IONPs@curcumin and IONPs@chitosan were mild toxic	[50]
Chloride, lactate, nitrate	IONPs@chloride, IONPs@lactate, and IONPs@nitrate	Wistar rats	100 mg/kg	14 days	No signs of toxicity	[51]
Human albumin	IONPs@human albumin	Wistar rats	2 mg Fe/kg	24 h	Firstly gathered in liver, then in spleen and kidney	[52]
Dimercaptosuccinic acid	IONPs@DMSA	C57BL/6 mice	15 mg Fe/kg	7, 30, 60, 90 days	No toxicity	[53]
/	ES-IONPs	U-87 MG tumor-bearing nude mice	5 mg Fe/kg	28 days	Accumulate in tumor	[54]
Poly (ethylene glycol) carboxyl-poly(ɛ-caprolactone)	PEG-PCCL-IONPs	H22 tumor xenograft BALB/c mice	20 mg/kg	48 h	Mainly distributed in the spleen and liver	[55]
Dextran	SPIONdex	Pig model	5 mg Fe/kg	30 min	No complement activation-related pseudoallergy observed	[56]
Lactobionic acid	MNP-LBA	Albino rabbit	25, 50 mg/kg	24 h	Enhance the release of ceftriaxone	[57]
Polyethylene glycol-COOH, Polyethylene glycol-NH₂	SPION@PEG-COOH and SPION@PEG-NH₂	BALB/c mice	0.8 mM Fe/kg	28 days	Mainly accumulated in the lung	[58]
Polyethylene glycol	PEG·SPIONs	Kunming mice	2.5 mg Fe/kg	14 days	Primarily in the liver, spleen, and intestine,	[59]
Didodecyl-dimethyl-ammonium-bromide, tocopheryl-polyetheleneglycol-succinate	SPION-DMAB, SPION-TPGS	Swiss albino mice	12.5 μg Fe/kg	7 days	SPION-DMAB mainly accumulated in brain and spleen, while SPION-TPGS internalized in liver and kidney	[60]
L-cysteine	Cys-Fe₃O₄ NPs	BALB/c mice	0.1 mg Fe/kg	7 days	Increase the adipose tissue in the inferior layer of the epidermis of mice	[61]
Poly(lactide)	PLA@SPIONs	Sprague Dawley rats	2 cm²	6 months	Slow degradation	[62]
Oleic acid and methoxy-polyethylene glycol-phospholipid	SPION-PEG2000	Swiss albino mice	12.5–50 mg/kg	14 days	Induced necrosis in liver and kidney and inflammatory infiltration in lung	[63]
Silica	sub-5 SIO-Fl	CD-1 mice	10 mg/kg	7 weeks	No obviously acute and chronic toxicity	[64]
/	SPION	Sprague Dawley rats	10–40 μg/mL	8 weeks	Enhanced the formation of chondrogenesis	[65]
Galactomannan	PSP-IO NPs	BALB/c mice	10–50 mg/kg	14 days	Increased the accumulation of methotrexate in the tumor site and decrease the toxicity of methotrexate	[66]
/	USPIONs	ICR mice	100 mg/kg	7 days	No significantly toxicity	[67]
Glypican-3-specific aptamer	Apt-USPIO	Kunming mice	1 mg Fe/mL	30 days	Excellent biocompatible	[68]

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