Fig. 8

Antibacterial activity of nanomaterials in the infected wound model and periodontal inflammation model in vivo. a H&E and Masson staining of the infected tissues on days 7 and 14. Scale bars are 100 μm. b Statistical analysis of cuticle thickness and intensity of collagen staining. c Immunostaining of infected skin tissues stained with CD31, α-SMA and DAPI on Day 7. Scale bars are 100 μm. d Quantifications of CD31 in the infected skin tissues. e The blood routine examination and major blood biochemical values of the control and treated groups in rats. The data are presented as mean ± SD (n = 5). Statistical significance: *P < 0.05, **P < 0.01; ***P < 0.001 and ****P < 0.0001