Fig. 3

Biosafety of NO^·@PLT. (A) The hemolysis rate of nano NO^· micelles and NO^·@PLT. Distilled water was used as the positive control, and 0.9% saline was used as the negative control. (B) Cell cytotoxicity of nano NO^· micelles and NO^·@PLT. (C) HE staining images of the tissue sections after injection of NO^·@PLT from the tail vein on mice. The mice treated with PBS were used as controls. Scale bar = 20 μm. (D) Measurement of biochemical blood indexes, including the levels of liver function (ALT and AST), kidney function (BUN and Cr), and inflammatory index (IL-6 and TNF-α) markers on day 28 in the NO^·@PLT treatment group. No significant difference, n.s