Fig. 5
From: The progression of inorganic nanoparticles and natural products for inflammatory bowel disease
Schematic diagram of the protective effect of SeNG in a colitis model. a A simple process for the synthesis of SeNG by emulsion. b The high binding affinity between HA and CD44 at the disease site enables effective inflammatory targeting. c In terms of mechanism, SeNG effectively clears ROS by directly eliminating and regulating the Nrf2 signaling pathway in the nucleus SeNG significantly up-regulates the expression of anti-ROS proteins (such as HO-1, SOD, CAT, GSH, and GST), and down-regulates the expression of iNOS and inflammatory factors (such as TNF-α and IL-6) (cited in Xu et al. [53])