Fig. 5

In vivo plaque targeting and biodistribution of trehalose-releasing nanogels in major organs. (A) The ex vivo fluorescence images of the aorta and (B) quantitative analysis of fluorescence signals accumulated in the aorta of ApoE^−/− mice after 24 h of IV with Cy5-TNG and free Cy5. (C, D) The ex vivo biodistribution images of Cy5-TNG and free Cy5 in major organs (heart, liver, spleen, lung, and kidney). Data are presented as mean ± SD, n = 3, ns: no significance, *p < 0.05 and **p < 0.01