Polymeric nanoparticles (PNPs) for oral delivery of insulin

Table 1 The material and their responsive condition in different formulations

PNPs	Nanoparticles	Responsive conditions	Refs.
MOFs^a	NU-100	pH	[21]
MOFs	UiO-68-NH₂	pH	[23]
MOFs	MIL-100	pH	[57]
MOFs	Ins-AuNPZIF-8	pH	[58]
COFs^b	TTA-DFP-nCOF	pH and glucose	[22]
PLGA^c	ChAuNps/PLGA	pH	[24]
PLGA/PEG^d	Pep/Gal-PNPs	pH	[49]
Soya protein	Soya protein NPs	pH and temperature	[43]
CS^e/ALG^f	CS/ALG core–shell NPs	pH	[48]
GBP^g	Hydrogel Networks	Glucose	[52]
DEGMA^h/AAPBAⁱ	p(AAPBA-b-DEGMA)	pH and glucose	[53]
Glucan	GOx^j@NACDD	Glucose	[54]
Glucan/PLGA	Polymersomes	pH	[59]
KGM^k/ConA^l	ConA-INS^m-KGM	Glucose	[55]
P(GAco-GAPBAPE)ⁿ/DSPE-PEG-Mal^o	Ins/NP-Fc	pH and glucose	[56]
Starch	Hydrogels	pH	[60]
CMCD^p/CMC^q	CMCD-g-CMC	pH	[61]
Zein	Zein-NPs	pH	[62]
Zein/casein/dextran	A1	pH	[63]
Zein/casein/dextran	A2	pH	[63]
Zein/casein/dextran	A3	pH	[63]
Silica	SINP	pH	[64]
Silica	SINP-PEG6000	pH	[64]
Silica	SINP-PEG20000	pH	[64]

^aMetal-organic frameworks
^bCovalent organic frameworks
^cPoly lactic-co-glycolic acid
^dPolyethylene glycol
^eChitosan
^fAlginate
^gGalactose binding protein
^hDiethylene glycol dimethacrylate
ⁱPoly 3-acrylamidophenyl boronic acid-b-diethylene glycol methyl ether methacrylate
^jGlucose oxidase
^kKonjac glucomannan
^lConcanavalin A
^mInsulin
ⁿPoly l-glutamic acid-co-l-glutamyl phenylboronic acid pinacol ester
^o1,2-distearoyl-sn-glycero-3-phosphoethanolamine-n-[maleimide polyethylene glycol
^pCarboxymethyl β-cyclodextrin
^qCarboxymethyl chitosan

ISSN: 1477-3155