Encapsulation and assessment of therapeutic cargo in engineered exosomes: a systematic review

Table 2 Engineered exosome as delivery vehicles for diverse drug types

Drug types	Drugs	Disease types	In vitro	In vivo	References
RNAs	miR-145-5p	Pancreatic ductal adenocarcinoma	Cancer cell proliferation and invasion↓	Cancerous cells apoptosis↑	[27]
	miR-183-5p	Breast cancer	Growth and metastasis of cancer cells↓	Tumor growth↓	[28]
	miR-1827	Colorectal	Cancer cell proliferation, migration, and invasion↓	Tumor growth and liver metastasis↓	[29]
	Cas9 mRNA	Breast cancer	Cancer cell growth↓	Tumor growth↓	[30]
	piRNA-18	Colon cancer	Cancer cell proliferation↓	Tumor proliferation, migration, and invasion↓	[31]
	circABCB10	Colorectal	Cancer cell growth↓	Tumor growth↓	[32]
Proteins	CIITA	Lymphoma	T cell response↑	T cell response↑	[33]
	NF-κB	Prostate cancer	Androgen receptor inhibition↑	Tumor growth↓	[34]
	TRAIL	Lymphoma	Leukocyte apoptosis↑	No effect on tumor growth	[35]
Compounds	Paclitaxel	Breast cancer	T cell ↑	Tumor growth↓	[36]
	Doxorubicin	Triple-negative breast cancer	Cancer cell growth↓	Tumor growth↓	[37]
	Curcumin	Glioblastoma	Glioblastoma cell growth↓	–	[38]

ISSN: 1477-3155