Table 3 Periodontium regeneration nanotherapeutic strategies for periodontitis treatment
Nanoparticles | Delivery systems | Drugs | Outcome | References |
|---|---|---|---|---|
L-Cys-AuNPs | Au nanoparticles | / | Promoted proliferation of human PDLCs, enhances their ALP activity and upregulated mRNA levels of osteogenic genes | [112] |
Nano-CaF2 | Polymeric nanoparticles | / | Increased levels of human PDLSCs and osteogenic genes in dental bone promote osseous differentiation and contribute to periodontium regeneration | [113] |
h-PDLSCs-exosomes | Exosomes | / | Upregulated of Runx2 and OCN mRNA levels in PDLSCs restores osteogenic differentiation in PDLSCs | [116] |
PLA/CS | PLA/CS nanofiber | / | Promoted proliferation and osteogenic differentiation of BMSCs and upregulated the expression level of osteogenic genes | [121] |
PLA/CA | PLA/CA nanofiber | / | Increased expression levels of cell mineralization genes and formation of mineralized junctions BMSCs, promoting osteogenic differentiation | [122] |
M2-Exos | Exosomes | / | Increased expression levels of osteogenesis in BMSCs while restrained expression levels of osteoclast formation in BMDM | [125] |
AMG-487 NP | Liposomal | AMG-487 NP | Reduced the number of osteoblasts and inhibits alveolar bone loss | [129] |
Fibrin-ACP | Chitosan nanoparticles | ε-aminohexanoic acid | Promoted the differentiation of cementoblasts | [134] |