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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: MiR-146b-5p enriched bioinspired exosomes derived from fucoidan-directed induction mesenchymal stem cells protect chondrocytes in osteoarthritis by targeting TRAF6

Fig. 2

Effects of MSCs-Exo and F-MSCs-Exo on inflammatory response and M1 polarization in vitro. (A, B) Western blot analysis was performed to detect the effects of MSCs-Exo and F-MSCs-ExoOD on inflammatory factors in chondrocytes induced by IL-1β. (C) The levels of IL-6, TNF-α, and PGE2 in the chondrocyte culture supernatant after IL-1β induction were measured using ELISA kits to assess the impact of MSCs-Exo and F-MSCs-Exo on these inflammatory mediators. (D, E) Flow cytometry was used to investigate the influence of MSCs-Exo and F-MSCs-Exo on M1 polarization. (ns, no significant difference; *p < 0.05; **p < 0.01; ***p < 0.001; n = 3)

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Journal of Nanobiotechnology

ISSN: 1477-3155

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