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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: MiR-146b-5p enriched bioinspired exosomes derived from fucoidan-directed induction mesenchymal stem cells protect chondrocytes in osteoarthritis by targeting TRAF6

Fig. 6

miR-146b-5p is a candidate effector for F-MSCs-Exo-mediated improvement in osteoarthritis. (A) A schematic diagram was presented to illustrate the process of miRNA sequencing and subsequent bioinformatics analysis. (B) The heat map showed the differential expression profile of miRNAs between MSCs-Exo and F-MSCs-Exo. (C, D) The pie chart and volcano plot displayed the distribution of up-regulated and down-regulated miRNAs between MSCs-Exo and F-MSCs-Exo. (E) KEGG enrichment analysis of F-MSCs-Exo was performed to investigate the potential biological pathways and processes affected by these miRNAs in the treatment of osteoarthritis. (F) Expression of up-regulated miRNAs in F-MSCs-Exo. (G) Targetscan was used to predict the binding site of rat miR-146b-5p and TRAF6

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Journal of Nanobiotechnology

ISSN: 1477-3155

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