Fig. 2

The development of renal epithelial cells was suppressed by PS-MPs plus HFD treatment. A UMAP of epithelial cells colored by four treatment groups (left) and epithelial cell subsets (right). B The proportion of epithelial cell subsets in the ND and HFD groups (left) and four treatment groups (right). C Heatmap of the top 10 DEGs among epithelial cell subsets according to log fold changes. D Violin plot of the top 3 DEGs among epithelial cell subsets according to log fold changes. E Pseudotime trajectory analysis colored by epithelial cell subsets at varying pseudotime stages (left) and by individual epithelial cell subsets (right). F GO enrichment analysis of down-regulation pathways of epithelial cells in PS-MPs group vs. ND group. G GO enrichment analysis of up-regulation pathways of epithelial cells in HFD group vs. ND group (left) and PS-MPs plus HFD group vs. ND group (right). H KEGG enrichment analysis of upregulation pathways of epithelial cells in HFD group vs. ND group (up) and PS-MPs plus HFD group vs. ND group (down)