Fig. 4
(A) The schedule of MRSA infection, systemic administration of MP-MENP, imaging diagnosis, and photo-immune eradiaction of infection in vivo. (B) PA images and (C) corresponding PA signal intensity of MRSA-infected area (red circles) from mice treated with MENP, MP-MENP, or mannose + MP-MENP. (D) T1-weighted and T2-weighted MR images and corresponding normalized (E) T1-weighted and (F) T2-weighted MR signal intensities of infected area in mice before and 6 h after i.v. injection with MP-MENP. (G) Thermal images of the infection regions upon laser irradition (808 nm 2 W/cm2, 5 min). (H) Representative digital photos and histological images of MRSA-infected region from mice with different treatments. The arrows in histological images indicate the inflammatory exudate and necrotic tissue. Scale bar: 40 μm. (I) Corresponding changes of wound areas. (J) The number of surviving MRSA on day 12 after treatment. * means P < 0.05, ** means P < 0.01, and *** means P < 0.001