Fig. 5

(A) The schedule of immuno-modulation process by MP-MENP. (B, C) IF results (F4/80⁺/CD86⁺: M1-type cell; F4/80⁺/CD206⁺: M2-type cell) of infected skin treated in different groups on days 2. (D) ELISA results of cytokines secreted by MRSA-infected tissues after different treatments. (E) IF results of HSP70, CD4⁺, and CD8⁺ T cells in infection microenvironment. (F) Transcriptomics analysis of the distribution of gene expression in control group (C1-C5)and MP-MENP mediated photothermal-immunotherapy group (T1-T5). (G) The volcano plots of the control vs. MP-MENP mediated photothermal-immunotherapy group. (H) The heat map of the reversed genes with significant differences. GO (I) and KEGG (J) enrichment analysis of the reversed genes. Nanotheranostic Trojan Horse for Visualization and Photo-Immunotherapy of Multidrug-Resistant Bacterial Infection