Fig. 4
In vivo 90Y-resin spheres brachytherapy enhanced by continuous hypoxia relief and NIR-II moderate PTT. (a) Schematic diagram of the therapeutic progress. (b). The average tumor growth curves of 4T1 subcutaneous tumors with various therapeutics (n = 5). Group I: Saline (control group); Group II: Pd@Au-PEG NSs + laser (moderate PTT); Group III: 90Y-micropsheres; Group IV: 90Y-micropsheres + Pd@Au-PEG NSs + laser. (c) The survival curves of tumor-bearing mice in each treatment group. (d) The weight curves of mice in each treatment group. (e) H&E staining, TUNEL assay and Ki67 staining of tumor samples from mice in four treatment groups (Scale bar = 50 μm)