Fig. 6
From: NOS-like activity of CeO2 nanozymes contributes to diminishing the vascular plaques
CeO2NPs prevent vascular plaque by NOS-like activity. (A) Cardiac ultrasound in living ApoE−/− mice with high-fat diet. (B) Ejection fraction (EF), fractional shortening (FS) and (C) left ventricular systolic/diastolic end volume-LV(s)/LV(d) are counted according to cardiac ultrasound data. (D) Oil-red staining to heart aorta valve and peripheral heart tissues. (E) Detection of serum TC, TG, LDL-C and HDL-C in mouse. (F) NO concentration in ApoE−/− mice serum is detected by the nitric oxide detection kit. (G) Mouse aortas are stripped and then stained by oil-red. (H-I) Immunohistochemical staining to the stripped aortas with CD68 antibody (H) and iNOS antibody (I). (J) After sacrificing the mice, arterial tissue proteins are extracted to detect the expression of iNOS, eNOS, CAT, SOD1 and Nrf2 by immunoblotting. Data is shown as mean ± SD, * p < 0.05, n = 5