Fig. 1
Properties of nanocomposite radiosensitizer. Size distributions of Au8 NCs (a), R837/BMS NPs (b), and R837/BMS@Au8 NPs (c). d Positive mode ESI-TOF-MS spectrum of Au8NCs. Insets: enlarged portion of the ESI-TOF-MS exhibiting isotopic distribution pattern. TEM images of Au8NCs (e), R837/BMS NPs (f), and R837/BMS@Au8 NPs (g). h Elemental mapping for the R837/BMS@Au8 NP. The element maps show distribution of Au, O, and N. i Elemental line scan shows core-shell structure of the R837/BMS@Au8 NP. j,k UV–Vis and fluorescence spectra of Au8NCs. l Zeta potentials of Au8NCs, R837/BMS NPs, and R837/BMS@Au8 NPs, n = 3. m Storage stability of R837/BMS@Au8 NPs. n Release profile of Au8NCs, R837, and BMS-1 from R837/BMS@Au8 NPs, n = 3. o Cytotoxicity assay of Au8NCs, R837/BMS NPs, and R837/BMS@Au8 NPs without radiation, n = 3. p Cytotoxicity assay of Au8NCs and R837/BMS@Au8 NPs with radiation (RT: radiotherapy). Data are presented as mean ± SD. Statistical significance was determined using the two tailed Student’s t-test. *P < 0.05, **P < 0.01 in comparison with RT group, n = 3