Fig. 5

In vivo therapeutic outcomes of MLNPs against HCC. (a) Schematic diagram of the establishment process of orthotopic liver cancer mouse model and treatment process. (b) The body weight, (c) liver weight, and (d) organ index of orthotopic liver cancer mice with the treatment of MLNPs. Each point represents the mean ± S.E.M. (n = 5; *p < 0.05 and **p < 0.01). The amounts of (e) BUN, (f) AST, (g) TBA, and (h) ALT in the serum. Each point represents the mean ± S.E.M. (n = 4; *p < 0.05, **p < 0.01, and ***p < 0.001). (i) Representative digital photos, TUNEL (Scale bar = 100 μm), (j) H&E (Scale bar = 100 μm), and Ki67 (Scale bar = 100 μm) staining images of the liver tissues from mice receiving oral treatment of MLNPs. Each point represents the mean ± S.E.M. (n = 3)