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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Multifunctional Fe-based coordination polymer nano-bomb modified with β-lapachone and CaO2 for targeted tumor dual chemodynamic therapy with enhanced ferroptosis and H2O2 self-supply

Fig. 4

Cytotoxicity and cellar uptake. a Cytotoxicity assay of 4T1 cells cultivated with different concentrations of HCF@β-lap. b Cytotoxicity assay of 4T1 cells cultivated with different treatment groups for 24 and 48 h, respectively. c Cellular uptake and intracellular distribution of different nanosystem in the 4T1 cells after incubation with PBS, Nile Red, CF@Nr, HCF@Nr or HCF@Nr + HA (pretreatment with HA for 2 h) for 24 h, detected by CLSM, the corresponding quantitative analysis of Nr fluorescence (d) and FCM (e). Nuclei and cytoskeleton were respective stained with DAPI (blue) and Alexa 488-phalloidin (green). Scale bar: 50 μm. Significance analysis was performed using a one-way ANOVA, ***p < 0.001

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Journal of Nanobiotechnology

ISSN: 1477-3155

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