Fig. 11

A Simplified mechanism of OXA-induced immunogenic cell death and autophagy-mediated DCs recruitment. B i: CLSM examination of CRT exposure in CT26 cells (scale bars: 10 µm) ii: CLSM examination of HMGB1 location in CT26 cells (scale bars: 10 µm) C ASN enhanced immune stimulation in vivo. i: Frequency of immature DCs in tumor tissue (n = 3). ii: Frequency of mature DCs in spleen (gated on CD11c + cells, n = 3). iii: Intratumoral infiltration of IFN-γ + CD4 + T cells post-treatment (gated on CD3 + , n = 3). iv: Intratumoral infiltration of IFN-γ + CD8 + T cells post-treatment (gated on CD3 + , n = 3). D ASN enhanced antitumor efficiency in vivo. i: Tumor growth curve during treatment (n = 6). ii: Tumor weight of CT26-bearing mice after treatment (n = 6). iii: Representative tumor images of mice post-treatment.